Tuesday, 24 May 2005
720

This presentation is part of: Organic Posters

P-Glycosyl-phosphonothiate O,O'-diesters

Kehinde A. Ajayi and Spencer Knapp. Rutgers University, Piscataway, NJ

Reaction of GlcNAc-alpha-mercaptan (1) with dialkyl N,N-diisopropylphosphoramidites gives the O,O'-dialkyl S-glycosylphosphothioate (2) or P-glycosyl-phosphonothioate (3) depending upon oxidation conditions. Mechanistic and other aspects of the rearrangement leading to (3) will be presented.


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