Monday, 23 May 2005 - 3:30 PM

This presentation is part of: Carbohydrates

Synthesis of 1-C-elaborated GalNAc-thiazolines

Benjamin Amorelli and Spencer Knapp. Rutgers University, Piscataway, NJ

The GalNAc-thiazoline (1) is an effective inhibitor of N-acetylhexosaminidases such as SpHEX. To improve inhibition and to study bioconjugation, we have prepared 1-C-elaborated analogues such as (2). This synthesis along with a unique rearrangement leading to the thiazole (3) will be presented.

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