Monday, 23 May 2005

This presentation is part of: Biological Chemistry Posters

Incorporation of the capsaicin receptor, TRPV1, into retroviral particles

Panagiotis Maniatis and Joseph Rucker. Villanova University, Villanova, PA

Research on membrane receptors is often complicated by the need to study them in the context of live cells. The technique of retroviral pseudotyping can be used to isolate plasma membrane proteins from the cell. We show that the complex membrane receptor TRPV1 can be incorporated into retroviral pseudotypes. Incorporation of TRPV1 requires expression of receptor at 32C, which suggests an effect of receptor activity on pseudotyping. The role of receptor activity on incorporation is currently being studied using both receptor mutagenesis and pharmacological methods.

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