Monday, 23 May 2005 - 3:00 PM

This presentation is part of: Organometallic-based Catalysis

Development of New Generation of Asymmetric Hydrogenation Catalysts

Xumu Zhang, Penn State University, University Park, PA

The aim of our research is to develop a highly active (10-100 times more turnovers than old generation of catalysts), highly enantioselective (>99%ee) new generation of hydrogenation catalysts with easier synthesis of chiral ligands, broad substrate scopes, high tolerance of substrate impurities. Examples with potential industrial applications will be given to illustrate the synthetic usages of new chiral ligands such as TangPhos, DuanPhos and Binapine. Our new chiral phosphines are electron-donating trialkyl phosphines with t-butyl groups and they are rigid. Discussions of these ligands discovered in 2000's will be given by comparing results with chiral phosphines invented in the 1980's (BINAP) and 1990's (DuPhos).

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