Monday, 23 May 2005: 1:30 PM-5:00 PM

Room 202 (Science & Engineering Resource Center)

Biological Chemistry (BIOL)

Gene Expression: Transcription

Transcription is the first step in gene expression, the primary regulated step in gene expression, and a validated target for antibacterial therapy. This symposium will cover recent developments in the structural biology, chemical biology, and single-molecule biophysics of transcription. Topics will include determination of three-dimensional structures of transcription complexes, characterization of small-molecule inhibitors of transcription, and single-molecule-nanomanipulation and single-molecule-spectroscopy analysis of transcription.
1:30 PM Welcoming Remarks
1:40 PM Structural studies of bacterial transcription
Seth A. Darst
2:15 PM Structure of bacterial RNA polymerase holoenzyme complexed with streptolydigin
Eddy Arnold, Steven Tuske, Stefan G. Sarafianos, Xinyue Wang, Brian Hudson, E. Sineva, Jayanta Mukhopadhay, Jens J. Birktoft, Oliver Leroy, Sajida Ismail, Arthur D. Clark Jr., Chhaya Dharia, Andrew Napoli, Oleg Laptenko, Jookyung Lee, Sergei Borukhov, Richard H. Ebright
2:50 PM Complexes of CAP in Transcription Activation
Catherine Lawson, Andrew A. Napoli, Brian Benoff, Helen M. Berman, Yon W. Ebright, Richard H. Ebright
3:25 PM Break
3:50 PM Direct Observation of Abortive Initiation and Promoter Escape: Single-Molecule DNA Nanomanipulation
Andrei Revyakin, Chenyu Liu, Terence Strick, Richard H. Ebright
4:25 PM Single-molecule-spectroscopy analysis of transcription
Achillefs Kapanidis

Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)