Monday, 23 May 2005: 9:00 AM-12:00 PM

Room 210 (Science & Engineering Resource Center)

ADMET at the Crossroads of Drug Discovery (ADME)


A potential drug is distinguished from a potent agonist /antagonist based on multiple factors affecting safety, exposure and marketability including drug metabolism and pharmacokinetic properties. In the past several years increasing attention has been focused on the potential involvement of drug transporters on drug distribution, pharmacokinetics and metabolism associated events. In the CNS pharmacological activities of drug have been shown to be attenuated by the activity of efflux transporters. In the liver and kidney uptake and efflux transporters have been associated with controlling the rate of drug clearance, enzyme induction and with potential toxicity. While in the intestine, drug transporters are involved in the selective absorption of nutrients and pharmacological agents. This symposium will present new research on the biochemistry and biology of transporters involved in various aspects of drug disposition, and the application of transporter research to facilitate drug design.
Workshop Leader:Jerome H. Hochman
9:00 AM Introductory Remarks
9:15 AM Perspectives into the Molecular and Functional Characteristics of Intestinal Oligopeptide Transporters
Gregory T. Knipp
9:45 AM Application of drug transport studies to drug discovery and development
Masayo Yamazaki
10:15 AM Role of Hepatic Transporters in the Disposition of Rosuvastatin
Liyue Huang
10:45 AM Break
11:00 AM Functional Characterization of a Hepatic Organic Anion Transport Model; OATP1B1 and MRP2 Double Transfected MDCKII cells
Kelly Bleasby, Richard Edom, Raymond Evers
11:30 AM Towards an understanding of organic anion transporters: structure-function relationships
Guofeng You

Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)