Monday, 23 May 2005: 9:00 AM-12:10 PM

Room 118 (Science & Engineering Resource Center)

Medicinal Chemistry (MEDI)

Pharmacetical Profiling I

Drug discovery research balances innovation of both potency and pharmaceutical properties. This symposium discusses state-of-the-art physicochemical, metabolic and toxicological property topics. While structure based design for potency optimization has been intensively studied, property based design concepts for absorption, pharmacokinetics and safety optimization are still emerging. Symposium topics explore the fundamentals and predictive approaches for transporters, CYP mechanisms, hERG, pharmacokinetics and toxicity. Concepts for increasing the impact of this information on drug discovery resarch projects through interfacing to teams, multivariate statistics, and applications in compound design will be discussed. Open discussion among speakers and with the audience will be facilitated as an important element of learning and advancement
Organizer:Edward H. Kerns
Presider:Edward H. Kerns
9:00 AM Overview of Pharmaceutical Profiling in Drug Discovery
Edward H. Kerns
9:15 AM In Silico Model for CYP Inhibition
Roy J. Vaz
9:55 AM Deciphering the Role of Drug Transporters in Early Drug Development: Cell Culture Models and Approaches
Patrick Sinko
10:35 AM Break
10:50 AM Biochemical and Molecular Assays In Early Toxicity Assessments: A Tier Approach
Prathibha S. Rao
11:30 AM Prediction of P450 Mediated Reactive Intermediate Formation
Ken Korzekwa

Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)